Returned from an amazing conference in Italy that was held in Ferrara, Italy October 8-10, 2010, the 2nd international Neural Prolotherapy Workshop. The importance of this conference is reflected by the large number of countries that were represented, with 27 doctors enrolled that came from Australia, USA, Mexico, New Zealand, Korea, Spain, Canada, Germany, India and Italy. The speaker, Dr. John Lyftogt presented the results of his research and taught the members the way he treats patients. I participated as one of his instructors. Neural Prolotherapy is a new therapeutic approach to chronic neuropathic pain, which until now has always been very difficult to treat with limited treatment options. Neuropathic pain is described as a debilitating pain that renders patients unable to walk, work, sleep and enjoy life. The other clinical features of neuropathic pain are hyperalgesia, allodynia and dysesthesia. Other important signs of neurogenic inflammation are the expansion of nerves and a degree of swelling and to a much lesser degree, heat and redness. Basically, neuropathic pain is due to neurogenic inflammation. The neurogenic inflammation is caused by the depletion or abnormal release of neuropeptides accumulated in the unmyelinated C fibers and A delta myelinated fibers in response to neuronal injury of these peptidergic sensory nerves. The abnormal regeneration of peptidergic sensory nerves results in neurogenic inflammation and chronic or neuropathic pain. Dr. John Lyftogt and his instructors showed that subcutaneous near nerve injections of dextrose can cause a instant analgesia with a reduction of neurogenic inflammation and improvement of neuropathic pain.